Collection:  Antibiotic Stewardship Guidelines and Algorithms Compendium

Compiled by IPRO HQIC

Urinary Tract Infection

UTI Guideline-6.9.21.pdf (

UTI.Complicated.Protocol.pdf (

clinicpath-nm-updated-uti-guidance_final-1.pdf (

International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases | Clinical Infectious Diseases | Oxford Academic (

Urinary Tract Infection (UTI) | Agency for Healthcare Research and Quality (

Clinical Practice Guidelines for the Antibiotic Treatment of Community-Acquired Urinary Tract Infections – PMC (

Urinary Tract Infections – Adult (

Toolkit for Reducing CAUTI in Hospitals | Agency for Healthcare Research and Quality (

Appendix K. Infographic Poster on CAUTI Prevention (

Clinical-Pearl-Single-dose-Aminoglycosides-for-Cystitis-1.17.23.docx.pdf (

Staphylococcus-aureus-in-urine-culture-4.26.23.pdf (

Clinical-Pearl-Aminopenicillins-for-Enterococcus-cystitis-7.19.23.docx.pdf (

Skin and Soft Tissue Infection

Cellulitis: A Review (JAMA)

Cellulitis: A Review (NIH)

Cellulitis: Information for Clinicians (CDC)

IDSA Skin & Soft Tissue guidelines 2014

Skin and Soft Tissue Infections: Treatment Guidance Updated May 2018 Jasmine R Marcelin MD, Trevor Van Schooneveld MD, Scott Bergman PharmD Reviewed by: Mark E Rupp MD, M. Salman Ashraf MBBS University of Nebraska. KALYANAKRISHNAN RAMAKRISHNAN, MD, ROBERT C. SALINAS, MD, AND NELSON IVAN AGUDELO HIGUITA, MD. Am Fam Physician. 2015;92(6):474-483

AAFP patient education materials

UCSF Medical Center Guideline for the Management of Suspected Skin and Soft Tissue Infections in Adults Original Author(s): Jennifer S. Mulliken, MD and Sarah M. Doernberg, MD, MAS

SHC Clinical Guideline: Outpatient Management of Skin and Soft Tissue Infections


Strategies to prevent surgical site infections in acute-care hospitals: 2022 Update with essential practices. 

Additional guidelines (all adapted from consensus guidelines):

ASHP Clinical Practice Guidelines for Prophylaxis in Surgery.

Stanford Health Care- Surgical Prophylaxis Guidelines

University of Michigan- Surgical Prophylaxis Guidelines

University of California San Francisco- Surgical Prophylaxis Guidelines

ICHE Compendium 2022- Updated Surgical Site Infection Prevention Compendium

IV to PO Conversion

Article – Intravenous-to-Oral Switch Therapy: Overview, Antibiotics, Antidepressants (

Article – (2023) – Switching patients from IV to oral antimicrobials – The Pharmaceutical Journal ( (from the UK)


Galway Antimicrobial Prescribing Policy / Guidelines (GAPP) – Galway: GAPP (

 (2018) Intravenous to Oral Conversion for Antimicrobials (

SHC-IV-to-PO-Interchange-Protocol.pdf (

A Resource To Help With Changing From IV To PO Antibiotics (

Public Health Ontario:

Community Acquired Pneumonia- Updated Recommendations ATS and IDSA 2020

ATS/IDSA Guidelines for Diagnosis and Treatment of Adults with Community Acquired Pneumonia 2019

C Difficile

Clinical-Pearl-CDI-Risk-2.8.23.pdf (

CDI Prevention Strategies-

MN Department of Health C difficile guidelines

UC Davis Guidelines 2021

University of Nebraska  2021

UNC Medical Center 2022

AHRQ  Best Practices in the Diagnosis and Treatment of C difficile 2019  

Management of C difficile in adults: review and comparison of IDSA/SHEA, ESCMID and ASID guidelines

IDSA C difficile clinical practice guidelines in adults: 2021 Update by SHEA/IDSA

April 18, 2023 LAN Event – Using TAP Strategy for HAI Reduction: CAUTI, CLABSI, C. Diff, MRSA

Prepared by IPRO HQIC

Join us for a webinar featuring subject matter experts from the Centers for Disease Control and Prevention (CDC) to learn about a comprehensive strategy to reduce hospital acquired infections (HAI). The Targeted Assessment for Prevention (TAP) Strategy is a CDC-developed framework for quality improvement that uses data to drive interventions that will prevent healthcare-associated infections. The TAP strategy targets healthcare facilities and specific units within facilities that have a disproportionate burden of HAIs so that prevention efforts can be prioritized and implemented where they will have the greatest impact. Our speakers will discuss the latest updates in the strategy and tools, including adaptation for smaller facilities.

Patient Stories Collection: Infectious Diseases

Compiled by IPRO HQIC

The following are websites where you can find patient stories related to infectious diseases:

1. Infectious Diseases Society of America (IDSA). IDSA Home [Internet]. Patient Stories: The Faces of Antimicrobial Resistance; [cited 2023 Aug 8]. Available from:

2. Pew Charitable Trusts. The Pew Charitable Trusts | The Pew Charitable Trusts [Internet]. True Stories of Antibiotic Resistance; 2017 Nov 13 [cited 2023 Aug 8]. Available from:

3. National Foundation for Infectious Diseases (NFID). NFID [Internet]. Real Stories, Real People – NFID; [cited 2023 Aug 8]. Available from:

4. Sepsis Alliance [Internet]. Faces of Sepsis; [cited 2023 Aug 11]. Available from:

5. Summa Health | Nonprofit Healthcare System in Akron, Ohio [Internet]. Infectious Disease Patient Stories | Summa Health; [cited 2023 Aug 11]. Available from:

6. Cleveland Clinic [Internet]. Infectious Disease Patient Stories | Cleveland Clinic; [cited 2023 Aug 11]. Available from:

7. St. Jude Children’s Research Hospital [Internet]. Infectious Diseases Treatment Patient Stories; [cited 2023 Aug 11]. Available from:

8. Patient Stories and Patient Safety [Internet] CDC. Published September 13, 2023. [Cited September 18, 2023]. Available from:

9. COVID-19 Patient Stories. [Internet] [Cited September 18, 2023]. Available from:

10. HQIC Antibiotic Stewardship Workgroup: Clostridioides difficile Module. [Internet] IPRO NQIIC. [Cited September 18, 2023]. Available from:

Joint HQIC Antibiotic Stewardship: Quick Wins for Improving Duration of Therapy – November 8, 2022 LAN Event

Prepared by IPRO HQIC

Antibiotic Stewardship (AS) remains a national priority aimed at optimizing antibiotic use to effectively treat infections, protect patients from harms caused by unnecessary use and combat antibiotic resistance. This event features national antibiotic use and duration of therapy (DOT) trending data, strategies to address AS challenges, examples of best practice to improve antibiotic discharge prescribing, and a hospital’s success with engaging leaders, providers and front-line staff in a hospital-wide initiative to improve DOT and outcomes.

HQIC Antibiotic Stewardship Workgroup- Clostridioides difficile Module

Prepared by IPRO QIN/QIO

Video interview with a nurse describing her own C.  difficile survival story. The story includes a first-person accounting of her yearlong hospitalization, the impact of antibiotic therapy, prevention of C. difficile and the long-term effects of this devastating antibiotic adverse event.

HQIC Antibiotic Stewardship Workgroup: Penicillin Allergy Module

Developed by the Network of Quality Improvement and Innovation Contractors for the Centers of Medicare and Medicaid Services Quality Improvement and Innovation Group – QIN/QIO HQIC

This resource contains two video conversations on how to develop and maintain a successful penicillin allergy program, and how to initiate and sustain an antibiotic allergy clarification program. Additional resources include CDC fact sheet, allergy poster, and Evaluation and Diagnosis of Penicillin Allergy for Healthcare Professionals documentation.

HQIC Webinar, November 4, 2021: Antibiotic Stewardship During A COVID Pandemic

This material was prepared by the IPRO NQIIC, a Network of Quality Improvement and Innovation Contractor, under contract with the Centers for Medicare & Medicaid Services (CMS), an agency of the U.S. Department of Health and Human Services (HHS)

This resources includes a recording and presentation slides from a November Webinar on Antibiotic Stewardship During the Covid Pandemic.

Antibiotic Stewardship (AS) is a national priority aimed at optimizing the use of antibiotics to effectively treat infections, protect patients from harms caused by unnecessary antibiotic use, and combat antibiotic resistance. Hospital AS Programs and teams have been challenged during the COVID pandemic to manage both viral and bacterial infections in patients for extended lengths of stay.